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Found 3 Enz. Inhib. hit(s) with Target = 'Bifunctional dihydrofolate reductase-thymidylate synthase' and Ligand = 'BDBM585318'
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585318(5-(4-(3-(tetrahydro-2H-pyran-4- yl)phenyl)piperazi...)
Affinity DataIC50:  1.10nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585318(5-(4-(3-(tetrahydro-2H-pyran-4- yl)phenyl)piperazi...)
Affinity DataIC50:  7.94nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585318(5-(4-(3-(tetrahydro-2H-pyran-4- yl)phenyl)piperazi...)
Affinity DataIC50:  34.7nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent