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Found 4 Enz. Inhib. hit(s) with Target = 'Breakpoint cluster region protein/Tyrosine-protein kinase ABL1' and Ligand = 'BDBM50325999'
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50325999(3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-...)
Affinity DataIC50:  267nMAssay Description:Inhibition of Bcr-abl tyrosine phosphorylation in mouse BA/F3ells p210 Bcr-abl after 90 mins by ELISAMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50325999(3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-...)
Affinity DataIC50:  267nMAssay Description:Inhibition of wild-type BCR-ABL (unknown origin) expressed in mouse Ba/F3 cells as cell growth inhibition after 48 hrs by MTT assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50325999(3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-...)
Affinity DataEC50:  140nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50325999(3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-...)
Affinity DataKd:  92nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair