Found 3 Enz. Inhib. hit(s) with Target = 'Broad substrate specificity ATP-binding cassette transporter ABCG2' and Ligand = 'BDBM50505460' TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hong Kong Polytechnic University
Curated by ChEMBL
Hong Kong Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of BCRP (unknown origin) transfected in human HEK293/R2 cells assessed as potentiation of topotecan-induced cytotoxicity measured as topot...More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hong Kong Polytechnic University
Curated by ChEMBL
Hong Kong Polytechnic University
Curated by ChEMBL
Affinity DataEC50: 2.10nMAssay Description:Inhibition of BCRP in human MCF7/MX100 cells assessed as reversal of topotecan resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hong Kong Polytechnic University
Curated by ChEMBL
Hong Kong Polytechnic University
Curated by ChEMBL
Affinity DataEC50: 4.20nMAssay Description:Inhibition of BCRP (unknown origin) transfected in HEK293/R2 cells assessed as reversal of topotecan resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
