Compile Data Set for Download or QSAR
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Found 7 Enz. Inhib. hit(s) with Target = 'C-C chemokine receptor type 3' and Ligand = 'BDBM50231358'
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50231358(1-((2R,3S)-4-((S)-3-(4-fluorobenzyl)piperidin-1-yl...)
Affinity DataIC50:  0.0380nMAssay Description:Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50231358(1-((2R,3S)-4-((S)-3-(4-fluorobenzyl)piperidin-1-yl...)
Affinity DataIC50:  0.0400nMAssay Description:Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Macaca fascicularis)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50231358(1-((2R,3S)-4-((S)-3-(4-fluorobenzyl)piperidin-1-yl...)
Affinity DataIC50:  0.150nMAssay Description:Antagonist activity at CCR3 receptor in cynomolgus monkey eosinophil assessed as as inhibition of chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50231358(1-((2R,3S)-4-((S)-3-(4-fluorobenzyl)piperidin-1-yl...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50231358(1-((2R,3S)-4-((S)-3-(4-fluorobenzyl)piperidin-1-yl...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50231358(1-((2R,3S)-4-((S)-3-(4-fluorobenzyl)piperidin-1-yl...)
Affinity DataIC50:  0.300nMAssay Description:Binding affinity to CCR3 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50231358(1-((2R,3S)-4-((S)-3-(4-fluorobenzyl)piperidin-1-yl...)
Affinity DataIC50:  0.870nMAssay Description:Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-stimulated intracellular calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed