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Found 6 Enz. Inhib. hit(s) with Target = 'C-C chemokine receptor type 5' and Ligand = 'BDBM50143740'
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143740((4-(4-(benzyl(phenyl)amino)piperidin-1-yl)-4-methy...)
Affinity DataIC50:  1.40nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143740((4-(4-(benzyl(phenyl)amino)piperidin-1-yl)-4-methy...)
Affinity DataIC50:  1.40nMAssay Description:Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143740((4-(4-(benzyl(phenyl)amino)piperidin-1-yl)-4-methy...)
Affinity DataIC50:  3nMAssay Description:Antagonistic activity against monkey C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Macaca fascicularis)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143740((4-(4-(benzyl(phenyl)amino)piperidin-1-yl)-4-methy...)
Affinity DataIC50:  3nMAssay Description:Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143740((4-(4-(benzyl(phenyl)amino)piperidin-1-yl)-4-methy...)
Affinity DataIC50:  12.2nMAssay Description:Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143740((4-(4-(benzyl(phenyl)amino)piperidin-1-yl)-4-methy...)
Affinity DataIC50:  14.4nMAssay Description:Migration of compound was evaluated in cellmigration assay with C-C chemokine receptor type 5-transfected L1.2 cells or activated human peripheral bl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed