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Found 8 Enz. Inhib. hit(s) with Target = 'Cannabinoid receptor 1' and Ligand = 'BDBM50267545'
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267545((4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfony...)
Affinity DataIC50:  0.100nMAssay Description:Displacement of [3H]SR141716 from human recombinant CB1R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267545((4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfony...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H] SR141716 from rat recombinant CB1R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267545((4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfony...)
Affinity DataIC50:  0.5nMAssay Description:Displacement of [3H]CP55940 from human recombinant CB1R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267545((4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfony...)
Affinity DataIC50:  2.20nMAssay Description:Displacement of [3H]CP55940 from rat recombinant CB1R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267545((4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfony...)
Affinity DataIC50:  9.20nMAssay Description:Antagonist activity at rat recombinant CB1R expressed in CHO cells assessed as inhibition of methanandamide-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267545((4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfony...)
Affinity DataEC50:  8nMAssay Description:Inverse agonist activity at human recombinant CB1R expressed in CHO cells assessed as increase in forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267545((4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfony...)
Affinity DataEC50:  5.80nMAssay Description:Agonist activity at human recombinant CB1R expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267545((4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfony...)
Affinity DataEC50:  3.40nMAssay Description:Agonist activity at rat recombinant CB1R expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed