Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) with Target = 'Carbonic anhydrase 2' and Ligand = 'BDBM11390'
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandPNGBDBM11390(2-(3-hydroxyphenyl)-3-(morpholin-4-ylmethyl)-1,1-d...)
Affinity DataKi:  0.150nM ΔG°:  -58.3kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandPNGBDBM11390(2-(3-hydroxyphenyl)-3-(morpholin-4-ylmethyl)-1,1-d...)
Affinity DataIC50: 1.15nMpH: 7.2 T: 2°CAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandPNGBDBM11390(2-(3-hydroxyphenyl)-3-(morpholin-4-ylmethyl)-1,1-d...)
Affinity DataIC50: 1.20nMAssay Description:Concentration which produces 50% inhibition of human Carbonic anhydrase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed