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Found 4 Enz. Inhib. hit(s) with Target = 'Cytochrome P450 2B6' and Ligand = 'BDBM50088447'
TargetCytochrome P450 2B6(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088447((+)-Artemisinin | CHEBI:223316)
Affinity DataKi:  4.60E+3nMAssay Description:Competitive reversible inhibition of CYP2B6 in human liver microsomes incubated for 3 mins prior to NADPH addition measured after 10 mins by Dixon pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088447((+)-Artemisinin | CHEBI:223316)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes incubated for 3 mins prior to NADPH addition measured after 10 mins by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088447((+)-Artemisinin | CHEBI:223316)
Affinity DataIC50:  1.21E+4nMAssay Description:Inhibition of recombinant CYP2B6 (unknown origin) incubated for 3 mins prior to NADPH addition measured after 10 mins by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088447((+)-Artemisinin | CHEBI:223316)
Affinity DataEC50:  600nMAssay Description:Induction of CYP2B6 in human hepatocytes after 72 hrs relative to vehicle-treated controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed