Compile Data Set for Download or QSAR
maximum 50k data
Found 4 Enz. Inhib. hit(s) with Target = 'Cytochrome P450 3A4' and Ligand = 'BDBM50088447'
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088447((+)-Artemisinin | CHEBI:223316)
Affinity DataKi:  2.50E+4nMAssay Description:Competitive inhibition of recombinant CYP3A4 (unknown origin) incubated for 3 mins prior to NADPH addition measured after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088447((+)-Artemisinin | CHEBI:223316)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin) incubated for 3 mins prior to NADPH addition measured after 3 mins by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088447((+)-Artemisinin | CHEBI:223316)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes incubated for 3 mins prior to NADPH addition measured after 3 mins by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50088447((+)-Artemisinin | CHEBI:223316)
Affinity DataEC50:  5.90E+3nMAssay Description:Induction of CYP3A4 in human hepatocytes after 72 hrs relative to vehicle-treated controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed