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Found 18 Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 1' and Ligand = 'BDBM50008935'
TargetDNA topoisomerase 1(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  21nMAssay Description:Poison activity at recombinant human TOP1 expressed in baculovirus infected Sf9 insect cells assessed as decrease in relaxed supercoiled pBS(SK+) DNA...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  21nMAssay Description:Inhibition of recombinant human Top1 expressed in baculovirus infected sf9 insect cells using supercoiled pBS (SK+) DNA as substrate incubated for 30...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  50nMAssay Description:Inhibition of topoisomerase I-DNA complex in trapping assayMore data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cellsMore data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibition of topoisomerase I activity was determined in vitro by using the cleavable complex assay(calf thymus)More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  1.08E+3nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  1.10E+3nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-I isolated from calf thymusMore data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  1.80E+3nMAssay Description:Poison activity at TOP1 in human MCF7 cells assessed as decrease in relaxed supercoiled pBS(SK+) DNA mobility measured after 30 mins by ethidium brom...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of Top1 in human MCF7 cells using supercoiled pBS (SK+) DNA as substrate incubated for 30 mins by ethidium bromide staining based agarose ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of human topoisomerase 1More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  5.25E+3nMAssay Description:Inhibition of DNA topoisomerase 1 in Homo sapiens (human) VACO 241 cellsMore data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  5.55E+3nMAssay Description:Inhibition of DNA topoisomerase 1 in Homo sapiens (human) HCT116 cellsMore data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  9.65E+3nMAssay Description:Inhibition of DNA topoisomerase 1 in Homo sapiens (human) SW480 cellsMore data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Mus musculus)
Life Science Research Center

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  2.00E+4nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  2.29E+4nMAssay Description:Inhibition of human topoisomerase I using DNA pBR322 as substrate assessed as DNA relaxation incubated for 45 mins by ethidium bromide staining based...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataEC50:  71.3nMAssay Description:Inhibition of topoisomerase-1 in human U251 cells assessed as inhibition of HIF-1-mediated hypoxia-induced VEGF expression after 24 hrs by luciferase...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataEC50:  54nMAssay Description:Inhibition of topoisomerase-1 in human U251 cells assessed as inhibition of hypoxia-induced HIF-1alpha accumulation in nuclear extract after 6 to 24 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataKd:  26.5nMAssay Description:Binding affinity to topoisomerase 1More data for this Ligand-Target Pair