Compile Data Set for Download or QSAR
maximum 50k data
Found 3 Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 1' and Ligand = 'BDBM50008936'
TargetDNA topoisomerase 1(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50008936((S)-10-Amino-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-o...)
Affinity DataIC50:  110nMAssay Description:Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50008936((S)-10-Amino-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-o...)
Affinity DataIC50:  1.80E+3nMAssay Description:Concentration required to inhibit 50% relaxation of 250 ng of SV40 DNA obtained with 0.5 I.U topoisomerase I at 37 degrees C for 30 minMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDNA topoisomerase 1(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50008936((S)-10-Amino-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-o...)
Affinity DataIC50:  4.20E+3nMAssay Description:Compound was tested in vitro for inhibition of topoisomerase I.More data for this Ligand-Target Pair
In DepthDetails Article