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Found 3 Enz. Inhib. hit(s) with Target = 'DNA-(apurinic or apyrimidinic site) endonuclease' and Ligand = 'BDBM83759'
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM83759((2,4,9-trimethylbenzo[b][1,8]naphthyridin-5-yl)ami...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human APE1 expressed in Escherichia coli rosetta using fluorescein-dabcyl-containing oligonucleotide as substrate after 5 mins by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM83759((2,4,9-trimethylbenzo[b][1,8]naphthyridin-5-yl)ami...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of N-terminal hexa-His tagged human APE1 expressed in Escherichia coli BL21 (Rosetta) using fluorescein-dabcyl-containing oligonucleotide ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM83759((2,4,9-trimethylbenzo[b][1,8]naphthyridin-5-yl)ami...)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of human recombinant APE1 after 15 mins by fluorescence based HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed