TargetDihydrofolate reductase(Pneumocystis carinii)
Indiana University School Of Medicine
Curated by ChEMBL
Indiana University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 23nMAssay Description:Binding affinity of the compound was reported with purified recombinant P. carnii Dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program
Curated by ChEMBL
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program
Curated by ChEMBL
Affinity DataKi: 55.6nMAssay Description:Binding affinity to human recombinant DHFR expressed in Escherichia coli BL21(DE3) by competitive binding assayMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Pneumocystis carinii)
Indiana University School Of Medicine
Curated by ChEMBL
Indiana University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 110nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Pneumocystis carinii.More data for this Ligand-Target Pair
Affinity DataKi: 112nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program
Curated by ChEMBL
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program
Curated by ChEMBL
Affinity DataKi: 410nMAssay Description:Inhibition of human DHFR using dihydrofolate as substrate after 180 secs by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program
Curated by ChEMBL
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program
Curated by ChEMBL
Affinity DataKi: 631nMAssay Description:Inhibitory activity against human lymphoblastoid cell (WIL2) dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
Affinity DataKi: 1.02E+3nMAssay Description:Inhibition of Escherichia coli DHFR assessed as NADP formation by quadratic Morrison plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.74E+4nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program
Curated by ChEMBL
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program
Curated by ChEMBL
Affinity DataKi: 4.30E+4nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Pneumocystis carinii)
Indiana University School Of Medicine
Curated by ChEMBL
Indiana University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 1.09E+5nMAssay Description:Inhibition of Pneumocystis carinii DHFRMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Indiana University School Of Medicine
Curated by ChEMBL
Indiana University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibitory activity of the compound was determined against dihydrofolate reductase in rat liver.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Pneumocystis carinii)
Indiana University School Of Medicine
Curated by ChEMBL
Indiana University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 450nMAssay Description:Inhibitory activity of the compound was determined against dihydrofolate reductase in Pneumocystis carinii at 37 cetigrade.More data for this Ligand-Target Pair
Affinity DataIC50: 2.09E+4nMAssay Description:Inhibition of Escherichia coli DHFR assessed as NADP formationMore data for this Ligand-Target Pair
Affinity DataKd: 1.18E+4nMAssay Description:Binding affinity to Escherichia coli DHFR at 500 uM using spyro orange reporter dye by differential scanning fluorimetryMore data for this Ligand-Target Pair