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Found 3 Enz. Inhib. hit(s) with Target = 'Dihydroorotate dehydrogenase (quinone), mitochondrial' and Ligand = 'BDBM470554'
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470554(4-ethyl-1-(2-fluoro-4-[(2-fluoro-6-methylphenyl)ca...)
Affinity DataIC50:  8.5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470554(4-ethyl-1-(2-fluoro-4-[(2-fluoro-6-methylphenyl)ca...)
Affinity DataIC50:  8.5nMAssay Description:DHODH enzymatic assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470554(4-ethyl-1-(2-fluoro-4-[(2-fluoro-6-methylphenyl)ca...)
Affinity DataIC50:  8.5nMAssay Description:The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller et al., 19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent