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Found 4 Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM581338'
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Ligature Therapeutics

US Patent
LigandPNGBDBM581338(US11504381, Compound 21 | US11548866, Compound 21)
Affinity DataKi:  1.50E+3nMAssay Description:The compounds binding to MDM2 were determined by a quantitative fluorescence polarization binding assay using a recombinant MDM2 protein and fluoresc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Ligature Therapeutics

US Patent
LigandPNGBDBM581338(US11504381, Compound 21 | US11548866, Compound 21)
Affinity DataKi:  1.50E+3nMAssay Description:The compounds binding to MDM2 were determined by a quantitative fluorescence polarization binding assay using a recombinant MDM2 protein and fluoresc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Ligature Therapeutics

US Patent
LigandPNGBDBM581338(US11504381, Compound 21 | US11548866, Compound 21)
Affinity DataKd:  400nMAssay Description:ITC experiments were run on a Malvern MicroCal Auto-ITC200 or ITC200 machine. Titration experiments were run in 20 mM Phosphate, 150 mM NaCl and 1 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Ligature Therapeutics

US Patent
LigandPNGBDBM581338(US11504381, Compound 21 | US11548866, Compound 21)
Affinity DataKd:  400nMAssay Description:ITC experiments were run on a Malvern MicroCal Auto-ITC200 or ITC200 machine. Titration experiments were run in 20 mM Phosphate, 150 mM NaCl and 1 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent