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Found 4 Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor' and Ligand = 'BDBM50161162'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Car

US Patent
LigandPNGBDBM50161162(AVL-292 | CC-292 | Spebrutinib | US10596172, Compo...)
Affinity DataIC50: <10nMAssay Description:EGFR (WT) and EGFR (T790M/L858R): The Omnia Assay Protocol for potency assessment against EGFR is performed as described in Example 251 above except ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Car

US Patent
LigandPNGBDBM50161162(AVL-292 | CC-292 | Spebrutinib | US10596172, Compo...)
Affinity DataIC50: <10nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Car

US Patent
LigandPNGBDBM50161162(AVL-292 | CC-292 | Spebrutinib | US10596172, Compo...)
Affinity DataIC50: <100nMAssay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Car

US Patent
LigandPNGBDBM50161162(AVL-292 | CC-292 | Spebrutinib | US10596172, Compo...)
Affinity DataIC50:  442nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged wild-type EGFR (695 to end residues) expressed in baculovirus infected Sf9 insect cells using p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed