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Found 5 Enz. Inhib. hit(s) with Target = 'Estrogen receptor' and Ligand = 'BDBM50121317'
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50121317(1,1-bis(4,4'-hydroxyphenyl)-2-phenylbut-1-ene | 4,...)
Affinity DataIC50:  0.0600nMAssay Description:Binding affinity to GST-tagged human ER alpha ligand-binding domain by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50121317(1,1-bis(4,4'-hydroxyphenyl)-2-phenylbut-1-ene | 4,...)
Affinity DataIC50:  3.30nMAssay Description:Antagonist activity at FLAG-tagged ERalpha (unknown origin) expressed in HEK293 cells assessed as reduction in E2-induced ER-alpha-mediated transcrip...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50121317(1,1-bis(4,4'-hydroxyphenyl)-2-phenylbut-1-ene | 4,...)
Affinity DataIC50:  15nMAssay Description:Antiestrogenic activity in MCF-7-2a cells as concentration required to reduce estradiol effect by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50121317(1,1-bis(4,4'-hydroxyphenyl)-2-phenylbut-1-ene | 4,...)
Affinity DataEC50:  1nMAssay Description:Selective estrogen receptor down-regulator activity at FLAG-tagged ERalpha (unknown origin) expressed in HEK293 cells assessed as induction of ERalph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50121317(1,1-bis(4,4'-hydroxyphenyl)-2-phenylbut-1-ene | 4,...)
Affinity DataEC50:  0.0150nMAssay Description:Agonist activity at ER in human MCF7:WS8 cells assessed as increase in cell growth by measuring DNA level after 7 days by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed