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Found 5 Enz. Inhib. hit(s) with Target = 'Farnesyl pyrophosphate synthase' and Ligand = 'BDBM50022663'
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50022663(CHEMBL3299047)
Affinity DataIC50:  200nMAssay Description:Inhibition of FPPS (unknown origin)More data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50022663(CHEMBL3299047)
Affinity DataIC50:  4.50E+3nMAssay Description:Allosteric inhibition of human recombinant FPPS using GPP and [3H]IPP as substrate incubated with enzyme for 10 mins prior to substrate addition by l...More data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50022663(CHEMBL3299047)
Affinity DataIC50:  5.00E+3nMAssay Description:Allosteric inhibition of N-terminal His-tagged human FPPS expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before addition of GPP a...More data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50022663(CHEMBL3299047)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50022663(CHEMBL3299047)
Affinity DataKd:  9.20E+3nMAssay Description:Binding affinity to human FPPS by isothermal titration colorimetry in absence of Mg2+ ionsMore data for this Ligand-Target Pair