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Found 3 Enz. Inhib. hit(s) with Target = 'GTPase KRas' and Ligand = 'BDBM50549225'
TargetGTPase KRas(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50549225(CHEMBL4750445)
Affinity DataIC50:  450nMAssay Description:Inhibition of N-terminal 6His-tagged/C-terminal Avi-tagged biotinylated GDP-bound human KRas G12D mutant (1 to 169 residues) assessed as reduction in...More data for this Ligand-Target Pair
TargetGTPase KRas(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50549225(CHEMBL4750445)
Affinity DataKd:  750nMAssay Description:Binding affinity to human GCP-KRAS G12D mutant (1 to 169 residues) expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
TargetGTPase KRas(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50549225(CHEMBL4750445)
Affinity DataKd:  750nMAssay Description:Binding affinity to GTP-KRAS G12D (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair