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Found
1
Enz. Inhib. hit(s) with Target = 'GTPase KRas [1-169,G12C,C118A]' and Ligand = 'BDBM544250'
Target
GTPase KRas [1-169,G12C,C118A]
(Homo sapiens (Human))
Amgen
US Patent
Ligand
BDBM544250
(6-Chloro-7-(2- chlorophenyl)-1-(2,4- diisopropyl-3...)
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Affinity Data
IC50: 37nM
Assay Description:
Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...
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Target Info
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Ligand Info
PC cid
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Details
US Patent
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