Compile Data Set for Download or QSAR
maximum 50k data
Found 4 Enz. Inhib. hit(s) with Target = 'Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2' and Ligand = 'BDBM50129273'
LigandPNGBDBM50129273(CHEMBL3629744)
Affinity DataIC50:  3nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129273(CHEMBL3629744)
Affinity DataIC50:  5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129273(CHEMBL3629744)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of gamma-secretase in HEK293 cell membranes using SPC99-Lon as substrate assessed as formation of amyloid beta 40 after 1 hr by electroche...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129273(CHEMBL3629744)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of gamma-secretase in HEK293 cell membranes using SPC99-Lon as substrate assessed as formation of amyloid beta 40 after 1 hr by electroche...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed