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Found 8 Enz. Inhib. hit(s) with Target = 'Glutamate receptor ionotropic, NMDA 1/2A' and Ligand = 'BDBM50062599'
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Chiba University

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  0.950nMAssay Description:Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/gluta...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Chiba University

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  911nMAssay Description:Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rattus norvegicus (Rat))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of eGFP-tagged rat GluN1-1a/GluN2A transfected in human tsA201 cells assessed as inhibition glutamate-induced current measured at -65 mV h...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rattus norvegicus (Rat))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  1.38E+3nMAssay Description:Antagonist activity at rat brain GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced channe...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Chiba University

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  2.30E+3nMAssay Description:Antagonist activity at GluN1a/GluN2A (unknown origin) expressed in Xenopus laevis oocytes at -60 mV holding potential by voltage clamp methodMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Chiba University

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  4.36E+3nMpH: 7.6Assay Description:Antagonist activity at NR1/NR2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced cur...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Chiba University

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of dexamethasone-induced human NR1-1a/NR2A receptor-mediated excitotoxicity in (S)-glutamate/glycine-stimulated mouse L12-G10 cells assess...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Chiba University

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of human GluN1-1a/NR2A receptor expressed in transgenic mouse fibroblast cells assessed as inhibition of L-glutamate-induced excitotoxicit...More data for this Ligand-Target Pair