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Found 15 Enz. Inhib. hit(s) with Target = 'Hepatocyte growth factor receptor' and Ligand = 'BDBM50347659'
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50:  2nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50:  2nMAssay Description:Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50:  26nMAssay Description:Inhibition of recombinant human c-MET phosphorylation at C-terminal Y1365More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50:  50nMAssay Description:Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1365 after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50:  56nMAssay Description:Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant human c-MET phosphorylation at C-terminal Y1349More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50:  900nMAssay Description:Inhibition of recombinant human c-MET phosphorylation at C-terminal Y1234More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50:  900nMAssay Description:Inhibition of recombinant human c-MET phosphorylation at C-terminal Y1235More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50:  900nMAssay Description:Inhibition of recombinant human c-MET phosphorylation at C-terminal Y1230More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: >2.50E+3nMAssay Description:Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1234 after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: >2.50E+3nMAssay Description:Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1235 after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataKd:  25nMAssay Description:Binding affinity to human recombinant His6-tagged unphosphorylated c-Met cytosolic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataKd:  4nMAssay Description:Binding affinity to human recombinant His6-tagged phosphorylated c-Met cytosolic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed