Found 45 Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM136597' TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of wild type TRKA (unknown origin) using TK-sub-biotin peptide as substrate incubated for 30 mins followed by treated with ATP and substra...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 0.730nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of the compound prepared by pre-diluting, and allowed...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 0.820nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of the compound prepared by pre-diluting, and allowed...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 0.860nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of the compound prepared by pre-diluting, and allowed...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of the compound prepared by pre-diluting, and allowed...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 0.960nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of the compound prepared by pre-diluting, and allowed...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 1.13nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of the compound prepared by pre-diluting, and allowed...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human His-tagged TRKA cytoplasmic domain (441 to 796 residues) expressed in insect cells using TK-sub biotin peptide substr...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Trk-A (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of wildtype TRKA (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 40 mi...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of wild type TRKA (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of TRKA (unknown origin) in presence of [gamma33P]ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of TRKA (unknown origin) assessed as reduction in incorporation of [33P]PO4 from [gamma-33P]-ATP using poly-EAY peptide as substrate by Fl...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of TRKA (unknown origin) by FISH assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Inhibition of N-terminal hexahistidine tagged TRKA (485 to 795 residues) (unknown origin) expressed in Sf9 cells using Ser/Thr 06 peptide as substrat...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of TrkA (unknown origin) using Tyr1 peptide as substrate in presence of ATP measured after 2 hrs by FRET-based Z-Lyte kinase assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 3.30nMAssay Description:Inhibition of recombinant human His-tagged TrkA catalytic domain (441 to 796 residues) expressed in baculovirus expression system using tyr 01 as sub...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of TrkA (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of TrkA (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of wild type TRKA (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 5.60nMAssay Description:Inhibition of TRKA (unknown origin) incubated for 30 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 5.90nMAssay Description:The HotSpot assay platform was used to measure kinase/inhibitor interactions as described in Anastassiadis et al., Nat Biotechnol. 29:1039-45, 2011. ...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 9.70nMAssay Description:An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 9.70nMAssay Description:An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 9.70nMAssay Description:Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 9.70nMAssay Description:Inhibition of TrkA (unknown origin) by cell based assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 9.70nMpH: 7.5Assay Description:An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 9.70nMpH: 7.5Assay Description:An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 4...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin) using TK-sub biotin peptide substrate preincubated for 30 mins followed by substrate addition and me...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of TRKA G623R mutant (unknown origin) using TK-sub biotin peptide substrate preincubated for 30 mins followed by substrate addition and me...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of TRKA F589L mutant (unknown origin) using TK-sub-biotin peptide as substrate incubated for 30 mins followed by treated with ATP and subs...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin) using poly-EAY peptide as substrate in presence of gamma-33ATP by LanthaScreen assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 69nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin) using poly-EAY peptide as substrate in presence of gamma-33ATP by LanthaScreen assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 109nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin) using TK-sub-biotin peptide as substrate incubated for 30 mins followed by treated with ATP and subs...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 109nMAssay Description:Inhibition of TRKA GS95R mutant (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 4...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 109nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin) using TK-sub biotin peptide substrate preincubated for 30 mins followed by substrate addition and me...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 237nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 272nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin) using Ser/Thr 06 peptide as substrate incubated for 1 hr in presence of 400 uM ATP by FRET based Z'-...More data for this Ligand-Target Pair
