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Found 5 Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM50111443'
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50111443(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Affinity DataIC50:  3.72E+3nMAssay Description:Inhibition of NGF-stimulated Trk AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50111443(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Affinity DataIC50:  5.88E+3nMAssay Description:Inhibition of NGF-stimulated Trk AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111443(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Affinity DataIC50:  5.88E+3nMAssay Description:Inhibition of binding of [125I]-NGF to TrkA in rat PC12 cells incubated for 2 hrs by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50111443(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Affinity DataIC50:  1.49E+5nMAssay Description:Inhibition of mouse NGF binding to TrkA (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111443(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Affinity DataEC50:  2.20E+4nMAssay Description:Inhibition of NGF-induced TrkA auto-phosphorylation in rat PC12 cells incubated for 15 mins by chemiluminescence based methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed