Found 5 Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM50578295' TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Veterinary Medicine Research & Development
Curated by ChEMBL
Veterinary Medicine Research & Development
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human TRKA at inactive state assessed as inhibition of substrate phosphorylation pretreated for 20 mins followed by substrate addition ...More data for this Ligand-Target Pair
3D Structure (crystal)TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Veterinary Medicine Research & Development
Curated by ChEMBL
Veterinary Medicine Research & Development
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human TRKA expressed in human U2OS cells assessed as inhibition of substrate hydrolysis pretreated for 30 mins followed by NGF agonist ...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Veterinary Medicine Research & Development
Curated by ChEMBL
Veterinary Medicine Research & Development
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human TRKA at inactive state assessed as inhibition of substrate phosphorylation using CSKtide as a substrate pretreated for 20 mins fo...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Veterinary Medicine Research & Development
Curated by ChEMBL
Veterinary Medicine Research & Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Binding affinity to human full length TRKA at active state expressed in rat PC-12 cells assessed as induction of kinase conformational change at 52 d...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Veterinary Medicine Research & Development
Curated by ChEMBL
Veterinary Medicine Research & Development
Curated by ChEMBL
Affinity DataEC50: 61nMAssay Description:Binding affinity to human full length TRKA at inactive state expressed in rat PC-12 cells assessed as induction of kinase conformational change at 40...More data for this Ligand-Target Pair
