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Found 4 Enz. Inhib. hit(s) with Target = 'Histone acetyltransferase KAT2B' and Ligand = 'BDBM50234932'
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
Genetech

US Patent
LigandPNGBDBM50234932(CHEMBL4103402 | US10239861, Example 20)
Affinity DataIC50:  12.7nMAssay Description:His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
Genetech

US Patent
LigandPNGBDBM50234932(CHEMBL4103402 | US10239861, Example 20)
Affinity DataIC50:  13nMAssay Description:Displacement of biotinylated small molecule ligand from His/FLAG-tagged PCAF bromodomain (719 to 832 residues) (unknown origin) after 15 mins by Alph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
Genetech

US Patent
LigandPNGBDBM50234932(CHEMBL4103402 | US10239861, Example 20)
Affinity DataIC50:  13nMAssay Description:Inhibition of biotinylated ligand binding to FLAG epitope-fused/His-tagged PCAF bromodomain (719 to 832 residues) (unknown origin) measured after 15 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
Genetech

US Patent
LigandPNGBDBM50234932(CHEMBL4103402 | US10239861, Example 20)
Affinity DataIC50:  49.6nMAssay Description:His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...More data for this Ligand-Target Pair
In DepthDetails US Patent