Found 33 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 8' and Ligand = 'BDBM50397360' 
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal His-tagged full length human HDAC8 expressed in baculovirus expression system using FAM-RHKK(TF-Ac)-NH2 substrate incubated ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.60nMAssay Description:Inhibition of recombinant HDAC8 (unknown origin) expressed in Escherichia coli using fluor de Lys(R) as substrate pretreated for 5 mins followed by s...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC8 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC8 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant HDAC8 using fluor de Lys as substrate preincubated for 5 mins followed by substrate addition measured after 25 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC8 (unknown origin) preincubated for 15 mins followed by acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin substrate addition and...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant HDAC8 using H2N-Arg-His-Lys(Ac)-Lys(Ac)-AMC as substrate after 90 mins by fluorescence based micro plate assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC8 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC8 (unknown origin) after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant HDAC8 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate preincubated for 15 mins fol...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of HDAC8 (unknown origin) measured by fluorometry assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant HDAC8 after 30 mins using fluorogenic substrate by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18.3nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant human HDAC8 using Boc-Lys (trifluoroacetyl)-AMC as substrate preincubated for 1 hr followed by substrate addition and measu...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of human HDAC8 using ZMTFAL as substrate measured after 90 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human full length C-terminal His-tagged HDAC8 expressed in baculovirus infected insect cells measured after 40 mins by HDAC...More data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of HDAC8 (unknown origin) (1 to 377 residues) expressed in Escherichia coli BL21(DE3) cells using Boc-Lys(TFA)-AMC as substrate preincubat...More data for this Ligand-Target Pair
Affinity DataIC50: 78nMAssay Description:Inhibition of human His-thioredoxin-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as substrate by fluorome...More data for this Ligand-Target Pair
Affinity DataIC50: 78nMAssay Description:Inhibition of recombinant human HDAC8 using Fluor de Lys as substrate preincubated for 90 mins followed by BML-KI176 addition measured after 45 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:Inhibition of recombinant human full length C-terminal His-tagged HDAC8 expressed in Escherichia coli BL21(DE3) using fluor de Lys(R) as substrate af...More data for this Ligand-Target Pair
Affinity DataIC50: 133nMAssay Description:Binding affinity to human HDAC8 pre-incubated for 10 mins before FITC-M344 addition and measured after 10 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Inhibition of HDAC8 by fluorometric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Schistosoma mansoni)
Martin-Luther University Of Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Of Halle-Wittenberg
Curated by ChEMBL
Affinity DataIC50: 436nMAssay Description:Inhibition of recombinant Schistosoma mansoni HDAC8 expressed in Escherichia coli using Fluor de Lys as substrate preincubated for 90 mins followed b...More data for this Ligand-Target Pair
3D Structure (crystal)TargetHistone deacetylase 8(Schistosoma mansoni)
Martin-Luther University Of Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Of Halle-Wittenberg
Curated by ChEMBL
Affinity DataIC50: 436nMAssay Description:Inhibition of Schistosoma mansoni His-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as substrate by fluoro...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Schistosoma mansoni)
Martin-Luther University Of Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Of Halle-Wittenberg
Curated by ChEMBL
Affinity DataIC50: 440nMAssay Description:Inhibition of Schistosoma mansoni HDAC8 using Fluor de Lys as substrate incubated for 90 mins by fluorescence methodMore data for this Ligand-Target Pair
Affinity DataIC50: 490nMAssay Description:Inhibition of human KDAC8 preincubated for 15 mins followed by acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin substrate addition measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human His-thioredoxin-tagged HDAC8 mL6/L179I mutant expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as subs...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human His-thioredoxin-tagged HDAC8 mL1/mL6/L179I mutant expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as ...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Schistosoma mansoni)
Martin-Luther University Of Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Of Halle-Wittenberg
Curated by ChEMBL
Affinity DataIC50: 9.33E+7nMAssay Description:Inhibition of Schistosoma mansoni KDAC8 using (FAM)-labeled peptide as substrate after 60 mins by microfluidic assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Schistosoma mansoni)
Martin-Luther University Of Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Of Halle-Wittenberg
Curated by ChEMBL
Affinity DataKd: 367nMAssay Description:Binding affinity to Schistosoma mansoni His-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells by ITC methodMore data for this Ligand-Target Pair
Affinity DataKd: 75nMAssay Description:Binding affinity to human His-thioredoxin-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells by ITC methodMore data for this Ligand-Target Pair
Affinity DataKd: 9.20nMAssay Description:Binding affinity to HDAC8 (unknown origin) by biolayer interferometry assayMore data for this Ligand-Target Pair
Affinity DataKd: 3.10nMAssay Description:Binding affinity to His-tagged recombinant human HDAC8 by SPR assayMore data for this Ligand-Target Pair
