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Found 5 Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase EZH2 [2-746,Y641N]' and Ligand = 'BDBM50246933'
TargetHistone-lysine N-methyltransferase EZH2 [2-746,Y641N](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50246933(CHEMBL4094432 | US10570121, Example 165)
Affinity DataIC50:  2nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2 [2-746,Y641N](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50246933(CHEMBL4094432 | US10570121, Example 165)
Affinity DataIC50:  5nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2 [2-746,Y641N](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50246933(CHEMBL4094432 | US10570121, Example 165)
Affinity DataIC50:  6nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2 [2-746,Y641N](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50246933(CHEMBL4094432 | US10570121, Example 165)
Affinity DataIC50:  443nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2 [2-746,Y641N](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50246933(CHEMBL4094432 | US10570121, Example 165)
Affinity DataIC50:  1.97E+3nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails US Patent