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Found 5 Enz. Inhib. hit(s) with Target = 'Indoleamine 2,3-dioxygenase 1' and Ligand = 'BDBM50138821'
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Newlink Genetics

US Patent
LigandPNGBDBM50138821(CHEMBL3747548 | US9617272, Compound 66 | US9981973...)
Affinity DataIC50:  5.50E+3nMAssay Description:The IC50 values for each compound were determined by testing the activity of IDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Newlink Genetics

US Patent
LigandPNGBDBM50138821(CHEMBL3747548 | US9617272, Compound 66 | US9981973...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of C-terminal 6His-tagged human IDO using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Newlink Genetics

US Patent
LigandPNGBDBM50138821(CHEMBL3747548 | US9617272, Compound 66 | US9981973...)
Affinity DataIC50:  1.00E+4nMAssay Description:The IC50 values for each compound were determined by testing the activity of IDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Newlink Genetics

US Patent
LigandPNGBDBM50138821(CHEMBL3747548 | US9617272, Compound 66 | US9981973...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human IDO1 assessed as conversion of N-formylkynurenine to kynurenine incubated for 1 hr by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Newlink Genetics

US Patent
LigandPNGBDBM50138821(CHEMBL3747548 | US9617272, Compound 66 | US9981973...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of IDO1 in IFNgamma-stimulated human HeLa cells incubated for 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed