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Found 3 Enz. Inhib. hit(s) with Target = 'Interleukin-1 receptor-associated kinase 4' and Ligand = 'BDBM384630'
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384630(4-{[trans-4-(4- acetylpiperazin-1- yl)cyclohexyl]a...)
Affinity DataIC50:  11nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384630(4-{[trans-4-(4- acetylpiperazin-1- yl)cyclohexyl]a...)
Affinity DataIC50:  122nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of 5 mM ATP by enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384630(4-{[trans-4-(4- acetylpiperazin-1- yl)cyclohexyl]a...)
Affinity DataIC50:  420nMAssay Description:Inhibition of IRAK4 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed