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Found 3 Enz. Inhib. hit(s) with Target = 'Interleukin-1 receptor-associated kinase 4' and Ligand = 'BDBM50242696'
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50242696(CHEMBL4083650 | US9932350, 2-5)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant human full length GST tagged IRAK4 expressed in baculovirus infected Sf9 cells using RP7030 peptide as substrate after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50242696(CHEMBL4083650 | US9932350, 2-5)
Affinity DataIC50:  7nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Rattus norvegicus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50242696(CHEMBL4083650 | US9932350, 2-5)
Affinity DataEC50:  1.70E+3nMAssay Description:Inhibition of IRAK4 in Lewis rat whole blood assessed as reduction in R848-stimulated TNF alpha production after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed