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Found 3 Enz. Inhib. hit(s) with Target = 'JAK3/JAK1' and Ligand = 'BDBM305821'
TargetJAK3/JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM305821((1r,3r)-3-(Cyanomethyl)-3-(4-(6-(1-methyl-1H-pyraz...)
Affinity DataIC50:  3.74E+3nMAssay Description:Inhibition of JAK1/JAK3 signaling pathway in human whole blood lymphocytes assessed as reduction in IL-2 induced STAT5 phosphorylation preincubated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetJAK3/JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM305821((1r,3r)-3-(Cyanomethyl)-3-(4-(6-(1-methyl-1H-pyraz...)
Affinity DataIC50:  4.84E+3nMAssay Description:Inhibition of JAK1/JAK3 signaling pathway in human whole blood lymphocytes assessed as reduction in IL-15 induced STAT5 phosphorylation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetJAK3/JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM305821((1r,3r)-3-(Cyanomethyl)-3-(4-(6-(1-methyl-1H-pyraz...)
Affinity DataIC50:  4.89E+3nMAssay Description:Inhibition of JAK1/JAK3 signaling pathway in human whole blood lymphocytes assessed as reduction in IL-21 induced STAT3 phosphorylation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed