Found 23 Enz. Inhib. hit(s) with Target = 'Melatonin receptor type 1A' and Ligand = 'BDBM50035179' TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
3D Structure (crystal)TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataKi: 0.0600nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataKi: 0.0600nMAssay Description:Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]-iodomelatonin as ra...More data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(GUINEA PIG)
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
TargetMelatonin receptor type 1A(GUINEA PIG)
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataKi: 0.100nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataKi: 0.100nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataKi: 0.100nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataKi: 0.120nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataKi: 0.120nMAssay Description:Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataKi: 0.180nMAssay Description:Binding affinity for human melatonin receptor type 1A, expressed in HEK-293 cells (2-[125I]-Iodomelatonin is used as radioligand)More data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataKi: 0.200nMAssay Description:The binding assay was performed in melatonergic MT1 and MT2 receptors in order to check the receptor affinity for the ligand, i.e., the ability of th...More data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataKi: 0.200nMAssay Description:The binding assay was performed in melatonergic MT1 and MT2 receptors in order to check the receptor affinity for the ligand, i.e., the ability of th...More data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 5.80E+6nMAssay Description:Agonist activity at human MT1 receptor expressed in HEK293 cells by Fluo-8 based calcium assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 1.60nMAssay Description:Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 1.40nMAssay Description:Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 1.40nMAssay Description:Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 1.60nMAssay Description:Agonist activity at human human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 2.65E+4nMAssay Description:Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-be...More data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 1.56nMAssay Description:Agonist potency determined by [35S]-GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataEC50: 1.40nMAssay Description:Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
