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Found 7 Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 2' and Ligand = 'BDBM50335255'
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50335255(3'-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-...)
Affinity DataKi:  60nMAssay Description:Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by liquid scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50335255(3'-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-...)
Affinity DataEC50:  27.5nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50335255(3'-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-...)
Affinity DataEC50:  380nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50335255(3'-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-...)
Affinity DataKd:  190nMAssay Description:Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50335255(3'-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-...)
Affinity DataEC50:  93nMAssay Description:Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50335255(3'-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-...)
Affinity DataEC50:  441nMAssay Description:Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293A cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50335255(3'-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-...)
Affinity DataEC50:  380nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK-293 cells assessed as thaillium flux through GIRK channelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed