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Found 3 Enz. Inhib. hit(s) with Target = 'Myeloperoxidase' and Ligand = 'BDBM434870'
TargetMyeloperoxidase(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM434870(7-{8,9,15-triazatetracyclo[16.3.1.12,6.18,11]tetra...)
Affinity DataIC50:  21nMAssay Description:Inhibition of MPO (unknown origin) chlorination activity incubated for 10 mins followed by NaCl addition by aminophenyl fluorescein assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM434870(7-{8,9,15-triazatetracyclo[16.3.1.12,6.18,11]tetra...)
Affinity DataIC50:  50nMAssay Description:MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM434870(7-{8,9,15-triazatetracyclo[16.3.1.12,6.18,11]tetra...)
Affinity DataIC50:  550nMAssay Description:MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent