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Found 6 Enz. Inhib. hit(s) with Target = 'NAD-dependent protein deacetylase sirtuin-1' and Ligand = 'BDBM50309831'
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50309831(10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of human recombinant SIRT1 expressed in Escherichia coli incubated at 37 degC for 2 hrs by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50309831(10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of human recombinant SIRT1 expressed in Escherichia coli using Fluor de Lys substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50309831(10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of human recombinant SIRT1 by Flour de Lys assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50309831(10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of recombinant human SIRT1 expressed in Escherichia coli using Fluor de Lys-SIRT1/2 substrate in presence of NAD+ by fluorescence micropla...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50309831(10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11...)
Affinity DataIC50:  9.80E+3nMAssay Description:Inhibition of human recombinant SIRT1 expressed in Escherichia coli cells using acetylated Lys side chain amino acids 379-382 (Arg-His-Lys-Lys(Ac)) p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50309831(10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11...)
Affinity DataIC50:  9.80E+3nMAssay Description:Inhibition of SIRT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed