BindingDB PrimarySearch

Found 24 Enz. Inhib. hit(s) with Target = 'Neuronal acetylcholine receptor subunit alpha-3/beta-4' and Ligand = 'BDBM50049757'

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

Ki: 0.150nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Istituto Di Chimica Biomolecolare

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

Ki: 0.150nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranesMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Istituto Di Chimica Biomolecolare

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

Ki: 0.220nMAssay Description:Displacement of [3H]epibatidine from alpha3beta4 nAChR (unknown origin) expressed in HEK cell membranes after 4 hrs by liquid scintillation counting ...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Istituto Di Chimica Biomolecolare

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

Ki: 0.230nMAssay Description:Binding affinity to human alpha3beta4 nAChRMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

Ki: 0.300nMAssay Description:Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in Xenopus oocytes using [3H]-epibatidine as radioligandMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

Ki: 0.380nMAssay Description:Displacement of [3H]epibatidine from Alpha3 Beta4 Nicotinic acetylcholine receptor of rat brain homogenatesMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Istituto Di Chimica Biomolecolare

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

Ki: 0.457nMAssay Description:Binding affinity of the compound was determined against Nicotinic acetylcholine receptor using [3H]-(-)-nicotine radioligandMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

Ki: 0.480nMAssay Description:Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta2 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

Ki: 0.480nMAssay Description:Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

Ki: 0.565nMAssay Description:Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta4 using [3H]epibatidineMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

Ki: 0.565nMAssay Description:Tested for binding affinity against Nicotinic acetylcholine receptor alpha3-beta4More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

Ki: 0.570nMAssay Description:Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha3-beta4More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

Ki: 0.570nMAssay Description:In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta4 using 0.5 nM [3H]epibatidineMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

Ki: 0.570nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nACHR expressed in human HEK293 cellsMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

EC50: 700nMAssay Description:Effective concentration against alpha3-beta4 nicotinic acetylcholine receptor (nAChR) expressed in IMR32 cell More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Istituto Di Chimica Biomolecolare

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

EC50: 28nMAssay Description:Agonist activity at alpha-3-beta-4 nAChR in KXalpha-3-beta-4R2 cells by rubidium efflux assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

EC50: 41nMAssay Description:Agonist activity at rat alpha3beta4 nAChR by cell-based rubidium flux assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

Kd: 0.300nMAssay Description:Tested for binding affinity against Nicotinic acetylcholine receptor alpha3-beta4More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

EC50: 128nMAssay Description:Inhibition of [3H]-epibatidine binding to Nicotinic acetylcholine receptor alpha4-beta2 from rat membranesMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Istituto Di Chimica Biomolecolare

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

EC50: 19nMAssay Description:Binding affinity against nicotinic acetylcholine receptor alpha3-beta4 using [3H]epibatidine as radioligand expressed in HEK293 cells or tsA cellsMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

EC50: 16nMAssay Description:Agonist activity at rat alpha3beta4 nAChR expressed in HEK292 cells assessed as increase of calcium influx by FLIPR assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Istituto Di Chimica Biomolecolare

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

Kd: 0.300nMAssay Description:Dissociation constant against Nicotinic acetylcholine receptor alpha3-beta4More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Istituto Di Chimica Biomolecolare

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

EC50: 7nMAssay Description:Compound was evaluated for functional potency and efficacy at human Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

EC50: 0.0370nMAssay Description:Effective concentration in KXalpha-3-beta-4R2 cells expressing rat nicotinic acetylcholine receptor alpha3-beta4 subunitsMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

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Filter my 24 hits

Targets 1▿
- Neuronal acetylcholine receptor subunit alpha-3/beta-4 24
Publications 16▿
- J Nat Prod 81: 1029-1035 (2018) 2
- J Med Chem 48: 5123-30 (2005) 2
- J Med Chem 46: 921-4 (2003) 2
- Bioorg Med Chem Lett 14: 271-3 (2003) 2
- Bioorg Med Chem Lett 14: 1889-96 (2004) 2
- J Med Chem 53: 8187-91 (2010) 2
- Bioorg Med Chem Lett 14: 1845-8 (2004) 2
- J Med Chem 48: 1721-4 (2005) 2
- J Med Chem 40: 4169-94 (1998) 1
- J Med Chem 49: 2673-6 (2006) 1
- J Med Chem 47: 6691-701 (2004) 1
- Bioorg Med Chem 28: (2020) 1
- Bioorg Med Chem Lett 15: 1221-4 (2005) 1
- Bioorg Med Chem Lett 14: 1855-8 (2004) 1
- Eur J Med Chem 152: 401-416 (2018) 1
- Bioorg Med Chem Lett 15: 4385-8 (2005) 1
Institutions 14▿
- University Of Illinois At Chicago 4
- Swiss Federal Institute Of Technology Zurich 2
- Georgetown University School Of Medicine 2
- University Of Wollongong 2
- Georgetown University Medical Center 2
- Research Triangle Institute 2
- Sri International 2
- Indiana State University 2
- Indian Institute Of Technology 1
- Columbia University College Of Physicians And Surgeons 1
- Abbott Laboratories 1
- Istituto Di Chimica Biomolecolare 1
- National Institute Of Diabetes And Digestive And Kidney Diseases 1
- University Of Auckland 1
Affinity: 0.037 to 7.0E+2 nM▿
- Ki 14
- Kd 2
- EC50 8
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1