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Found 7 Enz. Inhib. hit(s) with Target = 'Nicotinamide phosphoribosyltransferase' and Ligand = 'BDBM50011266'
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50011266(CHEMBL3260358)
Affinity DataIC50:  4nMAssay Description:Inhibition of NAMPT in human A2780 cells assessed as decrease in cell viability after 72 hrs by SRB assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50011266(CHEMBL3260358)
Affinity DataIC50:  6nMAssay Description:Inhibition of human full length C-terminal His6-tagged NAMPT expressed in Escherichia coli Rosetta (DE3) cells using nicotinamide as substrate incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50011266(CHEMBL3260358)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Rattus norvegicus)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50011266(CHEMBL3260358)
Affinity DataIC50:  35nMAssay Description:Inhibition of rat NAMPT after 30 mins by mass spectrometry-based analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Mus musculus)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50011266(CHEMBL3260358)
Affinity DataIC50:  59nMAssay Description:Inhibition of mouse NAMPT after 30 mins by mass spectrometry-based analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Mus musculus)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50011266(CHEMBL3260358)
Affinity DataEC50:  70nMAssay Description:Inhibition of NAMPT in mouse cells assessed as reduction in NAD level after 48 hrs by mass spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50011266(CHEMBL3260358)
Affinity DataEC50:  1.20nMAssay Description:Inhibition of NAMPT in human PC3 cells assessed as reduction in NAD level after 48 hrs by mass spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed