Compile Data Set for Download or QSAR
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Found 6 Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1' and Ligand = 'BDBM329924'
LigandPNGBDBM329924(US10463675, Example 7 | US10980815, Ex. No. 7 | US...)
Affinity DataIC50:  30nMAssay Description:Inhibition of JAK1/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IFN-alpha induced STAT3 phosphorylation preinc...More data for this Ligand-Target Pair
LigandPNGBDBM329924(US10463675, Example 7 | US10980815, Ex. No. 7 | US...)
Affinity DataIC50:  30nMAssay Description:Inhibition of JAK1/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IFN-alpha induced STAT3 phosphorylation preinc...More data for this Ligand-Target Pair
LigandPNGBDBM329924(US10463675, Example 7 | US10980815, Ex. No. 7 | US...)
Affinity DataIC50:  65nMAssay Description:Inhibition of JAK1/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-12 induced STAT4 phosphorylation preincubat...More data for this Ligand-Target Pair
LigandPNGBDBM329924(US10463675, Example 7 | US10980815, Ex. No. 7 | US...)
Affinity DataIC50:  65nMAssay Description:Inhibition of JAK1/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-12 induced STAT4 phosphorylation preincubat...More data for this Ligand-Target Pair
LigandPNGBDBM329924(US10463675, Example 7 | US10980815, Ex. No. 7 | US...)
Affinity DataIC50:  305nMAssay Description:Inhibition of JAK1/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-10 induced STAT3 phosphorylation preincubat...More data for this Ligand-Target Pair
LigandPNGBDBM329924(US10463675, Example 7 | US10980815, Ex. No. 7 | US...)
Affinity DataIC50:  305nMAssay Description:Inhibition of JAK1/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-10 induced STAT3 phosphorylation preincubat...More data for this Ligand-Target Pair