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Found 8 Enz. Inhib. hit(s) with Target = 'Nuclear receptor ROR-gamma' and Ligand = 'BDBM412666'
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM412666((S)-N-((5-(ethylsulfonyl)pyridin-2-yl)methyl)-7-is...)
Affinity DataKi: <100nMAssay Description:Compounds of the present invention were tested for ability to bind to ROR gamma in a cell-free competition assay with commercially available radio-li...More data for this Ligand-Target Pair
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TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM412666((S)-N-((5-(ethylsulfonyl)pyridin-2-yl)methyl)-7-is...)
Affinity DataKi: <100nMAssay Description:Compounds of the present invention were tested for ability to bind to RORγ in a cell-free competition assay with commercially available radio-li...More data for this Ligand-Target Pair
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TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM412666((S)-N-((5-(ethylsulfonyl)pyridin-2-yl)methyl)-7-is...)
Affinity DataKi: <100nMAssay Description:Compounds of the present invention were tested for ability to bind to RORγ in a cell-free competition assay with commercially available radio-li...More data for this Ligand-Target Pair
Ligand InfoPurchasePDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM412666((S)-N-((5-(ethylsulfonyl)pyridin-2-yl)methyl)-7-is...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of RORgamma (unknown origin)More data for this Ligand-Target Pair
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TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM412666((S)-N-((5-(ethylsulfonyl)pyridin-2-yl)methyl)-7-is...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human RORgamma by TR-FRET assayMore data for this Ligand-Target Pair
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TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM412666((S)-N-((5-(ethylsulfonyl)pyridin-2-yl)methyl)-7-is...)
Affinity DataIC50:  22nMAssay Description:Inhibition of RORgammat (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
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TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM412666((S)-N-((5-(ethylsulfonyl)pyridin-2-yl)methyl)-7-is...)
Affinity DataIC50: <100nMAssay Description:Compounds of the present invention were tested for ROR gamma inverse agonist activity in a cell-based, transcriptional activity assay. Secreted Nanol...More data for this Ligand-Target Pair
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TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM412666((S)-N-((5-(ethylsulfonyl)pyridin-2-yl)methyl)-7-is...)
Affinity DataIC50: <100nMAssay Description:Compounds of the present invention were tested for RORγ inverse agonist activity in a cell-based, transcriptional activity assay. Secreted Nanol...More data for this Ligand-Target Pair
Ligand InfoPurchasePDB