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Found 5 Enz. Inhib. hit(s) with Target = 'Nuclear receptor ROR-gamma' and Ligand = 'BDBM50466375'
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466375(CHEMBL4287674)
Affinity DataIC50:  13nMAssay Description:Transrepression of RORgammat in anti-CD3/CD28 stimulated human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466375(CHEMBL4287674)
Affinity DataIC50:  29nMAssay Description:Transrepression of recombinant human GAL4-DBD fused RORgammat LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466375(CHEMBL4287674)
Affinity DataIC50: <30nMAssay Description:Displacement of [3H]-Digoxin from recombinant human GST-fused RORgammat LBD after 1 to 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466375(CHEMBL4287674)
Affinity DataIC50:  200nMAssay Description:Transrepression of RORgammat in anti-CD3/CD28 stimulated C57BL/6 mouse CD4-positive T cells assessed as suppression of T cell differentiation to Th17...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466375(CHEMBL4287674)
Affinity DataIC50:  340nMAssay Description:Transrepression of recombinant mouse GAL4-DBD fused RORgammat LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed