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Found 4 Enz. Inhib. hit(s) with Target = 'P2X purinoceptor 7' and Ligand = 'BDBM50411885'
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50411885(CHEMBL257045)
Affinity DataIC50:  12.6nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50411885(CHEMBL257045)
Affinity DataIC50:  12.6nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50411885(CHEMBL257045)
Affinity DataIC50:  25.1nMAssay Description:Activity at rat P2X7 receptor expressed in HEK cells assessed as effect on BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50411885(CHEMBL257045)
Affinity DataIC50:  28.2nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed