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Found 3 Enz. Inhib. hit(s) with Target = 'Poly(ADP-ribose) glycohydrolase' and Ligand = 'BDBM371055'
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM371055(US10239843, Example 162)
Affinity DataIC50:  4nMAssay Description:PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM371055(US10239843, Example 162)
Affinity DataEC50:  9.20nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM371055(US10239843, Example 162)
Affinity DataEC50:  4.80nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed