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Found 2 Enz. Inhib. hit(s) with Target = 'Polymerase basic protein 2' and Ligand = 'BDBM552316'
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen Biopharma

US Patent
LigandPNGBDBM552316((1a*S,11b*S,20a*S)-22,23-difluoro-17-hydroxy-1a,2,...)
Affinity DataIC50:  6nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen Biopharma

US Patent
LigandPNGBDBM552316((1a*S,11b*S,20a*S)-22,23-difluoro-17-hydroxy-1a,2,...)
Affinity DataEC50:  1.40nMAssay Description:Human lung carcinoma A549 cells (ATCC, Manassas, Va.) were plated at a density of 5×104 cells/mL (10×103 cells/well) in assay media (Ham's F12 me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent