Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) with Target = 'Procathepsin L' and Ligand = 'BDBM19855'
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

LigandChemical structure of BindingDB Monomer ID 19855BDBM19855(N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-(4-propyl...)
Affinity DataIC50: 503nM EC50:  48nMpH: 5.5 T: 2°CAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2008
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

LigandChemical structure of BindingDB Monomer ID 19855BDBM19855(N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-(4-propyl...)
Affinity DataIC50: 48nMAssay Description:Inhibition of cathepsin L in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

LigandChemical structure of BindingDB Monomer ID 19855BDBM19855(N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-(4-propyl...)
Affinity DataKi:  503nMAssay Description:Inhibition of human cathepsin-L using Z-Phe-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2016
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

LigandChemical structure of BindingDB Monomer ID 19855BDBM19855(N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-(4-propyl...)
Affinity DataKi:  3.26E+3nMAssay Description:Inhibition of human cathepsin L using Z-Phe-Arg-pNA chromogenic substrate fluorogenic substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed