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Found 9 Enz. Inhib. hit(s) with Target = 'Prostaglandin D2 receptor 2' and Ligand = 'BDBM50296977'
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Oxagen

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataKi:  13nMAssay Description:Antagonistic activity at CRTH2 in human eosinophils assessed as inhibition of PGD2-induced calcium mobilization after 60 mins by Fluo-3 based fluores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Oxagen

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataIC50:  6nMAssay Description:Displacement of [3H]PGD2 from human prostaglandin D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Oxagen

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataIC50:  19nMAssay Description:Antagonist activity at CRTH2 expressed in Th2 cells assessed as inhibition of PGD2-induced IL13 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Oxagen

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataIC50:  28nMAssay Description:Antagonist activity at CRTH2 expressed in Th2 cells assessed as inhibition of PGD2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Oxagen

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataIC50:  35nMAssay Description:Antagonist activity at CRTH2 expressed in Th2 cells assessed as inhibition of PGD2-induced antiapoptotic activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Oxagen

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataIC50:  44nMAssay Description:Displacement of [3H]PGD2 from human prostaglandin D2 receptor in presence of human serum albuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Oxagen

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataIC50:  100nMAssay Description:Inhibition of CRTH2 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Oxagen

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataIC50:  130nMAssay Description:Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Oxagen

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataEC50:  24nMAssay Description:Antagonist activity at CRTH2 in human eosinophils assessed as inhibition of PGD2-induced shape changeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed