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Found 8 Enz. Inhib. hit(s) with Target = 'Prostaglandin F2-alpha receptor' and Ligand = 'BDBM520995'
TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM520995((+)-5-[({6-Bromo-3-methyl-2-[(2H8)pyrrolidin-1-yl]...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM520995((+)-5-[({6-Bromo-3-methyl-2-[(2H8)pyrrolidin-1-yl]...)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin F2-alpha receptor(Rattus norvegicus)
Bayer

Curated by ChEMBL
LigandPNGBDBM520995((+)-5-[({6-Bromo-3-methyl-2-[(2H8)pyrrolidin-1-yl]...)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at rat FPR stably expressed in CHO cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin F2-alpha receptor(MOUSE)
Bayer

Curated by ChEMBL
LigandPNGBDBM520995((+)-5-[({6-Bromo-3-methyl-2-[(2H8)pyrrolidin-1-yl]...)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at FPR in mouse NIH3T3 cells assessed as inhibition of PGF2alpha-induced cytokine induced neutrophil attracting chemokine product...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM520995((+)-5-[({6-Bromo-3-methyl-2-[(2H8)pyrrolidin-1-yl]...)
Affinity DataIC50:  15nMAssay Description:For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin F2-alpha receptor(MOUSE)
Bayer

Curated by ChEMBL
LigandPNGBDBM520995((+)-5-[({6-Bromo-3-methyl-2-[(2H8)pyrrolidin-1-yl]...)
Affinity DataIC50:  18nMAssay Description:Antagonist activity at FPR in mouse NIH3T3 cells assessed as inhibition of PGF2alpha-induced MCP1 production measured after 24 hrs by Bio-Rad assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM520995((+)-5-[({6-Bromo-3-methyl-2-[(2H8)pyrrolidin-1-yl]...)
Affinity DataIC50:  22nMAssay Description:Displacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin F2-alpha receptor(Rattus norvegicus)
Bayer

Curated by ChEMBL
LigandPNGBDBM520995((+)-5-[({6-Bromo-3-methyl-2-[(2H8)pyrrolidin-1-yl]...)
Affinity DataIC50:  52nMAssay Description:Antagonist activity at FPR in Wistar rat assessed as inhibition of PGF2alpha-induced uterus contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed