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Found 13 Enz. Inhib. hit(s) with Target = 'Proteasome subunit beta type-5' and Ligand = 'BDBM50069985'
TargetProteasome subunit beta type-5(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataKi:  1.40nMAssay Description:Competitive inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate measured for 10 mins by fluor...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of 20S constitutive proteosome beta5c subunit (unknown origin) assessed as substrate hydrolysis using Z-Leu-Leu-Leu-al as substrateMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataKi:  3.70nMAssay Description:Inhibition of chymotrypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataKi:  4nMAssay Description:Inhibition of 20s constitutive proteasome beta5 chymotrypsin-like activity in human erythrocytes using Suc-Leu-Leu-Val-Tyr-AMC as substrate after 10 ...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataKi:  70nMAssay Description:Inhibition of 20s immunoproteasome beta5 chymotrypsin-like activity in human spleen using Suc-Leu-Leu-Val-Tyr-AMC as substrate after 10 mins by fluor...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of chymotrypsin like activity of 26S proteasome beta 5 subunit (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human platelet Thromboxane synthetaseMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataIC50:  7nMAssay Description:Inhibition of 20S proteosome beta 5 purified from human HCT116 cells using Suc-LLVY-AMC as substrate incubated for 30 to 120 mins by fluorimetryMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataIC50:  9nMAssay Description:Inhibition of chymotrypsin-like activity of proteasome beta-5 subunit in HEK293 cells using Suc-LLVY-Glo as substrate incubated for 2 hrs prior to su...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataIC50:  11nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome beta 5 subunit assessed as hydrolysis of succinyl-LLVY-AMC fluorogenic substrate mea...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataIC50:  25nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate by fluorometric methodMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataIC50:  30nMAssay Description:Inhibition of chymotrypsin-like activity of beta5 subunit of 20S proteasome in human erythrocytes using Suc-LLVY-MCA as substrate preincubated with e...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataIC50:  37nMAssay Description:Inhibition of chymotrypsin-like activity of 20S human proteasome assessed as Suc-LLVY-AMC hydrolysis at using Promega proteasome-Glo-3 substrate incu...More data for this Ligand-Target Pair