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Found 3 Enz. Inhib. hit(s) with Target = 'Protein O-GlcNAcase' and Ligand = 'BDBM458384'
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM458384(1-[6-[(3R,5S)-1-[(6-fluoro-2-methyl-1,3-benzothiaz...)
Affinity DataIC50:  0.782nMAssay Description:The OGA enzyme catalyses the removal of O-GlcNAc from nucleocytoplasmic proteins. To measure this activity Fluorescein di-N-acetyl-β-N-acetyl-D-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM458384(1-[6-[(3R,5S)-1-[(6-fluoro-2-methyl-1,3-benzothiaz...)
Affinity DataIC50:  0.782nMAssay Description:Inhibition of full-length human N-terminal poly-His tagged OGA expressed in baculovirus infected Sf9 cells using FD-GlcNAc as substrate preincubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM458384(1-[6-[(3R,5S)-1-[(6-fluoro-2-methyl-1,3-benzothiaz...)
Affinity DataIC50:  0.782nMAssay Description:The OGA enzyme catalyses the removal of O-GlcNAc from nucleocytoplasmic proteins. To measure this activity Fluorescein di-N-acetyl-β-N-acetyl-D-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent